How do we know what really works?

We were founded in 2013 on a simple truth: a value-based system requires evidence of what works for every patient population, not just those represented in randomized trials. It also needs the mechanisms to deliver this evidence efficiently and with confidence.

Our mission is to power critical decisions in healthcare with data science-driven technology.

Building on decades of experience in epidemiology and health outcomes research, our founders joined forces with out-of-industry technologists to develop the Aetion Evidence Platform®—an extensible engine to tap into the vast potential of real-world data.

Since then, we’ve continued to innovate in all things essential insights, and a complementary suite of RWD-ready apps: Discover for broad exploration, Substantiate for big decisions, Replica Synthesis for synthetic data and more and more secure data. All told, it’s all you need to power real-world evidence at scale.

Today, our solutions are used worldwide to make meaning from real-world data, and meaningful results for life sciences companies, payers, regulators, and HTA agencies.

Our name

We are often asked how to say our name, and where the name came from. Aetion (“ay-tee-on”) is adapted from the Greek word for causality—reflecting our deep roots in the science of using real-world data to draw causal conclusions.

Our investors

NEA logo

New Enterprise Associates, Inc. (NEA) is a global venture capital firm focused on helping entrepreneurs build transformational businesses across multiple stages, sectors and geographies. With more than $20 billion in cumulative committed capital since the firm’s founding in 1977, NEA invests in technology and health care companies at all stages in a company’s lifecycle, from seed stage through IPO. The firm’s long track record of successful investing includes more than 220 portfolio company IPOs and more than 370 acquisitions.

Warburg Pincus is a leading global private equity firm focused on growth investing. The firm has more than $60 billion in private equity assets under management. The firm’s active portfolio of more than 200 companies is highly diversified by stage, sector, and geography. Select health care investments include Alignment Healthcare, Experity, and Summit Health. Founded in 1966, Warburg Pincus has raised 19 private equity funds, which have invested more than $90 billion in over 930 companies in more than 40 countries.

flare capital partners logo

Flare Capital Partners is a team of proven healthcare technology venture capital investors known for their unparalleled strategic industry resources, insight and total commitment to the success of its entrepreneurs. Flare Capital raised one of the health care industry’s largest dedicated venture capital funds focused exclusively on early stage and emerging growth investments in healthcare technology innovation and is privileged to closely partner with founders and management. Selected investments include Aetion, Bright Health, Circulation, ClearDATA, Evolent Health, HealthReveal, HealthVerity, Iora Health and Welltok.

lakestar logo

Lakestar is a global venture capital firm, investing in internet and technology companies worldwide, with offices in London, Berlin, Zurich and New York. Selected investments include Spotify, Opendoor, Facebook, Airbnb, SOFI,, Klarna, Skype, Oscar Healthcare, Harry’s Shaving, Maker Studios, Algomi, and Teralytics, as well as many earlier stage companies in the US and Europe. Lakestar maintains an entrepreneur-centric approach, enabling stellar management teams to accomplish their full potential.

Town Hall Ventures is an investment firm, founded in 2018 and headquartered in New York and Minneapolis, that invests in health care companies primarily serving vulnerable populations covered by Medicare and Medicaid. With deep experience building businesses, serving in major public and private sector roles, building premier executive teams, and investing across technology and health care, Town Hall partners with entrepreneurs to build transformational businesses from the idea stage to the growth stage.

Greenspring Associates was founded in 2000 to focus solely on venture capital investments. Through a comprehensive platform, the Firm serves as a lifecycle partner for fund managers and entrepreneurs, investing across multiple stages, sectors, and geographies. Greenspring Associates currently manages over $11 billion in committed capital across a variety of specialized venture strategies on behalf of a diverse group of global investors.

Aetion is proud to have leading life sciences, payer, and health care services firms, as well as global tech funds, as strategic investors, including B Capital, Foresite Capital, McKesson Ventures, Sanofi Ventures, EDBI, Amgen Ventures, Johnson & Johnson Innovation — JJDC, Inc., UCB, Horizon Health Services, Inc.

News & Events

News & Events

J.P. Morgan 42nd Annual Healthcare Conference

The state of innovation in a volatile market.